منابع مشابه
Repolarization reserve: a moving target.
Clinicians are well aware that responses to QT-prolonging drugs vary among individuals.1 A drug dose (and concentration) that produces minimal QT prolongation in one patient may, in an apparently indistinguishable subject, produce marked QT prolongation and torsade de pointes. This variability in response to an exogenous stressor is paralleled by variability in the extent to which a given mutat...
متن کاملDiclofenac Prolongs Repolarization in Ventricular Muscle with Impaired Repolarization Reserve
BACKGROUND The aim of the present work was to characterize the electrophysiological effects of the non-steroidal anti-inflammatory drug diclofenac and to study the possible proarrhythmic potency of the drug in ventricular muscle. METHODS Ion currents were recorded using voltage clamp technique in canine single ventricular cells and action potentials were obtained from canine ventricular prepa...
متن کاملSubunit interaction determines IKs participation in cardiac repolarization and repolarization reserve.
BACKGROUND The role of IKs, the slow delayed rectifier K+ current, in cardiac ventricular repolarization has been a subject of debate. METHODS AND RESULTS We develop a detailed Markov model of IKs and its alpha-subunit KCNQ1 and examine their kinetic properties during the cardiac ventricular action potential at different rates. We observe that interaction between KCNQ1 and KCNE1 (the beta-sub...
متن کاملReduced repolarization reserve in ventricular myocytes from female mice.
OBJECTIVE Cardiac repolarization is prolonged and repolarization reserve (RR) is diminished in female rabbits and humans, compared to males. Reduced RR is evidenced by the relatively greater increase in ventricular action potential duration (APD) in myocytes from females in response to drugs that block repolarizing K(+) currents. Mice are an increasingly important experimental model animal for ...
متن کاملDiabetes mellitus attenuates the repolarization reserve in mammalian heart.
OBJECTIVE In diabetes mellitus several cardiac electrophysiological parameters are known to be affected. In rodent experimental diabetes models changes in these parameters were reported, but no such data are available in other mammalian species including the dog. The present study was designed to analyse the effects of experimental type 1 diabetes on ventricular repolarization and its underlyin...
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ژورنال
عنوان ژورنال: Heart Rhythm
سال: 2011
ISSN: 1547-5271
DOI: 10.1016/j.hrthm.2011.06.024